150 MG

Pharmacotherapeutic Group: Antimycotics for systemic use, Triazole derivatives;

MECHANISM OF ACTION

Fluconazole is a triazole antifungal agent. Its primary mode of action is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of fluconazole

THERAPEUTIC INDICATIONS

• Fluconazole is indicated in adults for the treatment of:
• Cryptococcal meningitis
• Coccidioidomycosis
• Invasive candidiasis.
• Mucosal candidiasis including oropharyngeal, oesophageal candidiasis, candiduria and chronic mucocutaneous candidiasis.
• Chronic oral atrophic candidiasis (denture sore mouth) if dental hygiene or topical treatment are insufficient.
• Vaginal candidiasis, acute or recurrent; when local therapy is not appropriate.
• Candidal balanitis when local therapy is not appropriate.
• Dermatomycosis including tinea pedis, tinea corporis, tinea cruris, tinea versicolor and dermal candida infections when systemic therapy is indicated.
• Tinea unguinium (onychomycosis) when other agents are not considered appropriate.

Paediatric population

A maximum dose of 400 mg daily should not be exceeded in paediatric population.

As with similar infections in adults, the duration of treatment is based on the clinical and mycological response. Fluconazole is administered as a single daily dose

HOW TO TAKE MICONIX?

- Oropharyngeal Candidiasis

• 200 mg PO on Day 1, THEN 100 mg qDay

- Esophageal Candidiasis

• 200 mg PO on Day 1, THEN 100 mg qDay; doses up to 400 mg/day may be used based on patient’s response

- Cryptococcal Meningitis

• 400 mg PO on Day 1, THEN 200 mg PO qDay

- Prevention of candidiasis incidence in patients undergoing bone marrow transplant

• 400 mg PO qDay

- Vaginal Candidiasis

• Uncomplicated: 150 mg PO as a single dose
• Complicated: 150 mg PO q72hr for 3 doses
• Recurrent: 150 mg PO qDay for 10-14 days followed by 150 mg once weekly for 6 months

- Candida UTI/Peritonitis

• 50-200 mg PO qDay