500 MG
FILM COATED TABLETS

Pharmacotherapeutic group: Antibacterials for systemic use, macrolides.

Mechanism of actions

Azithromycin is an azalide, a sub-class of the macrolide antibiotics. By binding to the 50Sribosomal sub-unit, azithromycin avoids the translocation of peptide chains from one side of the ribosome to the other. As a consequence of this, RNA-dependent protein synthesis in sensitive organisms is prevented.

THERAPEUTIC INDICATIONS

Azithromycin is indicated for the following bacterial infections induced by micro-organisms susceptible to azithromycin:

• Acute bacterial sinusitis (adequately diagnosed)
• Acute bacterial otitis media (adequately diagnosed)
• Pharyngitis, tonsillitis
• Acute exacerbation of chronic bronchitis (adequately diagnosed)
• Mild to moderately severe community acquired pneumonia
• Infections of the skin and soft tissues of mild to moderate severity e.g. folliculitis, cellulitis, erysipelas
• Uncomplicated Chlamydia trachomatis urethritis and cervicitis

DOSING AND ADMINISTRATION

The recommended dose in adults and children over 45 kg is 500 mg (1 tablet), taken once a day, for 3 days. For some diseases, such as Chlamydia, the recommended dose is 1 g (2 tablets) taken together on a single day.
Izaral should not be taken by children weighing less than 45 kg.